Extra-Esophageal Pepsin from Stomach Refluxate Promoted Tonsil Hypertrophy

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Extra-Esophageal Pepsin from Stomach Refluxate Promoted Tonsil Hypertrophy.

BACKGROUND Gastroesophageal reflux is associated with numerous pathologic conditions of the upper aerodigestive tract. Gastric pepsin within reflux contributes to immunologic reactions in the tonsil. In this study, we aimed to find the relationships between pepsin and tonsillar hypertrophy. METHODS AND FINDING We explored the notion whether tonsillar hypertrophy was due to pepsin-mediated gas...

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Bile acids in laryngopharyngeal refluxate: will they enhance or attenuate the action of pepsin?

OBJECTIVES/HYPOTHESIS To assess if, as previously reported in the literature, bile acids inhibit pepsin activity, resulting in pepsin having a less important role in laryngopharyngeal damage in reflux disease. STUDY DESIGN Prospective translational research study. METHODS A total of 78 patient's fasting gastric juice samples were obtained from routine endoscopy. The total bile acid (TBA) co...

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Human papillomavirus causing tonsillar hypertrophy in non-cancerous tonsil

Human papillomavirus (HPV) is associated with the development of most anogenital carcinomas, including cervical cancer and, has more recently been suggested to be a risk factor for a subset of head and neck squamous cell carcinoma. A 15-year-old female presented with complaints of chronically progressive pain on swallowing. Examination revealed bilateral Grade III tonsillar enlargement with mul...

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Adenoid and Tonsil Hypertrophy in Children and Facial Malformations

The controversy over the influence of nasal breathing on facial bone development has continued for decades and otolaryngologists are often questioned on this subject. The pharynx is a segment of the airway whose walls are soft and shaped primarily by the constrictor muscles and tongue, which attributes a very dynamic character. This tract is also delimited by the adenoids, tonsils and the lingu...

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Factors associated with lingual tonsil hypertrophy in Canadian adults

BACKGROUND Hypertrophy of the lingual tonsil tissue in the adult patient is thought to contribute to the pathophysiology of obstructive sleep apnea. The underlying etiology of lingual tonsil hypertrophy (LTH) in the adult patient is unclear and likely multifactorial. Previous studies have suggested that the lingual tonsils may undergo compensatory hyperplasia post-tonsillectomy in children, alt...

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ژورنال

عنوان ژورنال: PLOS ONE

سال: 2016

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0152336